职称：青年副研究员
电子邮箱：wlihua@fudan.edu.cn
办公地点：东一楼334室
电话：021-54237656
个人网页/课题组主页：
研究方向：
肿瘤细胞中物质能量代谢与细胞器重塑的作用
脂类代谢在细胞命运调控中的作用与机制
重要学术贡献：
（1）脂类代谢通过影响线粒体重塑调控细胞多能性；
（2）多不饱和脂肪酸DHA合成抑制神经母细胞瘤发生发展及其调控机制；
（3）GAPDHS通过调控黑色素瘤细胞中糖酵解进而影响肿瘤进展；
（4）LACTB 通过干扰PP1A和YAP的相互作用抑制黑色素瘤进展。
荣誉与获奖：
2017年获中国科学院天然免疫与慢性疾病重点实验室优秀研究论文奖；
2016年获安徽省普通高等学校品学兼优毕业生与中国科学技术大学优秀毕业生荣誉称号；
2013年获中国科学技术大学优秀学生干部荣誉称号；
发表论文：
1.Fatty acid synthesis is critical for stem cell pluripotency via regulating mitochondrial fission, EMBO J., 2017. 36(10): p. 1330-1347, Lihua Wang#, Tong Zhang, Lin Wang, Yongping Cai, Xiuying Zhong, Xiaoping He, Lan Hu, Shengya Tian, Mian Wu, Lijian Hui, Huafeng Zhang*and Ping Gao*（IF=11.598）
2.MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2, Journal of Experimental & Clinical Cancer Research, 2019 Dec 19;38(1), Yi Ding#, Jie Yang#, Yawen Ma, Tengteng Yao, Xingyu Chen, Shengfang Ge*, Lihua Wang* and Xianqun Fan*（IF=11.161）
3.Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells, Cell Metabolism 29, 1–14 March 5, 2019, Xiuying Zhong#, Peng Cui, Yongping Cai, Lihua Wang, Xiaoping He, Peipei, Lu Kangyang, Yan Ronghui, Zhang Ying, Pan Xin, Zhao Xiaoyang, Li Wei, Huafeng Zhang*, Qi Zhou* & Ping Gao*（IF=27.287）
4.LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction, Cancer Letter, 2021 Mar 04;506, Yawen Ma #, Lihua Wang #,Fanglin He#, Jie Yang, Yi Ding, Shengfang Ge , Xianqun Fan,Yixiong Zhou, Xiaofang Xu, Renbing Jia * （IF=8.679）
5.Sperm-specific glycolysis enzyme GAPDHS mediates transcription factor SOX10 to promote uveal melanoma tumorigenesis, Frontiers Cell and Developmental Biology, 2021;9，10.3389/fcell.2021.610683， Xia Ding#, Lihua Wang#, Mingjiao Chen#, Yue Wu, Ge Shengfang, Jin Li*, Xianqun Fan*, Ming Lin*（IF=6.684）
6.The role of mitochondrial dynamics in human cancers, American Journal of Cancer Research, Am J Cancer Res 2020;10(5):1278-1293, Yawen Ma#, Wang Lihua*, Jia Renbing*（IF=6.161）
7.Role of de novo cholesterol synthesis enzymes in cancer, Journal of Cancer, 2020; 11(7): 1761-1767, Yang Jie#, Wang Lihua*, Jia Renbing*（IF=4.207）
8.Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications, Life Science Alliance, (2019), DOI 10.26508/lsa.201900413, Shengya Tian, Junru Feng, Yang Cao,…, Lihua Wang, Huafeng Zhang, Xiuying Zhong, Ping Gao et al（IF=4.591）
9.Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis, BBA-molecular basis of disease, Molecular Basis of Disease, (2018),Li Peng, Li Yongyun, Zhu Liqi, Yang Zhi, He Jie, Wang Lihua,…, Fan Xianqun, Ge Shengfang, Jia Renbing, Zhang He et al（IF=5.187）
10.CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis , EMBO Reports, 2017.05, 18(5): 809~825, Zhong Xiuying, Tian Shengya,…, Wang Lihua, Song Libing, Zhang Huafeng, Pan Xin, Li Ailing, Gao Ping et al（IF=8.807）
11.Human Fibroblast Reprogramming to Pluripotent Stem Cells Regulated by the miR19a/b-PTEN Axis, Plos One, (2014), Xiaoping He, Yang Cao, Lihua Wang,…, Huafeng Zhang, Ping Gao et al（IF=3.24）