电子邮件/Email
yunlongyang@fudan.edu.cn
教育经历及职位/Education
2024至今, 复旦大学上海医学院 细胞与遗传医学系 主任
2022至今, 复旦大学上海医学院 教授
2019-2024, 复旦大学上海医学院 细胞与遗传医学系 副主任
2017-2022, 复旦大学上海医学院 研究员
2017-2017, 瑞典卡罗林斯卡医学院，研究人员
2012-2016, 瑞典卡罗林斯卡医学院，博士后研究员
2009-2011, 瑞典卡罗林斯卡医学院，联合培养博士研究生
2006-2011, 复旦大学 上海医学院 遗传学专业 博士研究生
2002-2006, 同济大学 生命科学与技术学院 生物技术专业 本科生
主持基金/Grants
2023-2026,“万人计划”青年拔尖人才
2023、2024, 基础医学地高建学科交叉科研项目
2019-2022, 上海高校特聘教授“东方学者”
2018-2020, 浦江人才
2018、2024, NSFC面上项目
2017-2018, 引进人才启动基金
教育教学/Teaching
2023, 国家级一流本科课程 负责人，教育部
2021, 复旦大学荣誉课程 负责人，复旦大学
2021, 上海高等学校一流本科课程 负责人，上海市教委
发表论文/Publications
Google Scholar：https://scholar.google.com/citations?user=joh17pwAAAAJ&hl=en
Research Gate：https://www.researchgate.net/profile/Yunlong-Yang-13
主要研究兴趣为：1、肿瘤血管生物学及其微环境的转化医学研究；2、肿瘤、脂肪相关的代谢研究； 3、肿瘤血管、淋巴管转移不同步骤的分子机制及抗转移策略； 4、正常组织血管微环境及其病理机制的转化医学研究。
Research Interest: 1. Translational research on tumor angiogenesis and tumor microenvironment; 2. Translational research on tumor- and adipose tissue-associated metabolism; 3. Mechanistic research on tumor metastasis and anti-metastatic strategies; 4. Translational research on normal tissue vascular biology.
杨云龙，理学博士，教授，博士生导师，系主任。25篇第一/通讯作者论文发表于 Nature, Cell Metabolism, Science Translational Medicine, Gut, Nature Communications, Cancer Research, PNAS，Cell Reports等刊物(下划线标注代表作)。代表作被选为Nature Reviews Endocrinology、Cancer Cell等研究亮点、Science Translational Medicine、Advanced Science等封面文章、Nature Communications编辑推荐、ESI高被引文章、被Science、Cancer Discovery等刊物报道。受邀在Seminars in Cancer Biology, Advanced Drug Delivery Reviews, Chinese Medical Journal，Cancer Pathogenesis and Therapy等刊物发表综述及社论。2011年至今发表文献60篇，影响因子总和813分，篇均=13.5。总引用3000余次。H指数为30。以第一发明人获批专利8项(ZL201711310808.X；ZL201711310791.8；ZL201810179243.4；ZL201810398743.7；ZL201810400082.7；ZL201810407248.8；ZL201910463388.1; ZL201910596001X)。
1. Xu D, Li Y, Ye Y, Gao M, Zhang Y, Che Y, et al. Super-assembled niobium-MXene integrated frameworks for accelerated bone repair and osseointegration. Nano Today. 2024 Sep 5; 59:102471. doi: /10.1016/j.nantod.2024.102471 (IF 13.2)
2. Luo Z, Mei J, Wang X, Wang R, He Z, Geffen Y, et al. Voluntary exercise sensitizes cancer immunotherapy via the collagen inhibition-orchestrated inflammatory tumor immune microenvironment. Cell Reports. 2024 Aug 31;43(9):114697. doi: 10.1016/j.celrep.2024.114697 (IF 7.5)
3. Chen R, Cheng T, Xie S, Sun X, Chen M, et al. Effective prevention and treatment of acute leukemias in mice by activation of thermogenic adipose tissues. Advanced Science. 2024 Jul 25:e2402332. doi: 10.1002/advs.202402332 (IF 14.3; Cover article)
4. Guo Z, Xu J, Sun X, Sun S, Yang Y, and Cao Y. Tumor angiogenesis and antiangiogenic therapy. Chinese Medical Journal. 2024 Jul 25. doi: 10.1097/CM9.0000000000003231 (IF 7.5)
5. Yang Y, Wu C, Zhu W. Connecting Scientists and Oncologists for Advances. Cancer Pathogenesis and Therapy. 2024 Jul 1.doi: 10.1016/j.cpt.2024.06.006 (IF N/A)
6. Mei J, Cai Y, Xu R, Lv X, Li Q, Chu J, et al. Conserved immuno-collagenic subtypes predict response to immune checkpoint blockade. Cancer Communications. 2024 Mar 20. doi: 10.1002/cac2.12538 (IF 20.1)
7. Liang Y, Kong L, Zhang Y, Zhang Y, Shi M, Huang J, et al. Transfer RNA derived fragment, tRF-Glu-CTC, aggravates the development of neovascular age-related macular degeneration. Theranostics. 2024 Jan 27; 14(4):1500-1516. doi:10.7150/thno.92943 (IF 12.4)
8. Sun X, Sui W, Mu Z, Xie S, Deng J, Li S, et al. Mirabegron displays anticancer effects by globally browning adipose tissues. Nature Communications. 2023 Nov 22;14(1):7610. doi: 10.1038/s41467-023-43350-8 (IF 14.7; Editors’ Highlights in Nature Communications)
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10. Yang Y, Zhong J, Cui D, Jensen LD. Up-to-date molecular medicine strategies for management of ocular surface neovascularization. Advanced Drug Delivery Reviews. 2023 Sep 7;201:115084. doi: 10.1016/j.addr.2023.115084 (IF 15.2)
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14. Hosaka K, Wang C, Zhang S, Lv X, Seki T, Zhang Y, et al. Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors. Cancer Communications. 2023 Jun;43(6):637-660 (IF 20.1; Cover article)
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16. Xie S, Jiang C, Wu M, Ye Y, Wu B, Sun X, et al. Dietary ketone body-escalated histone acetylation in megakaryocytes alleviates chemotherapy-induced thrombocytopenia. Science Translational Medicine. 2022 Nov 30;14(673):eabn9061 (IF 15.8; Cover article; comment in Cancer Pathogenesis and Therapy)
17. Yang Y. Editorial: The Adipose Tissue Microenvironment in Cancer: Molecular Mechanisms and Targets for Treatment. Frontiers in Cell and Developmental Biology. 2022 Oct 19;13:954645 (IF 4.6)
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23. Yang Y, Cao Y. The impact of VEGF on cancer metastasis and systemic disease. Seminars in Cancer Biology. 2022 Mar 17;86(Pt 3):251-261. doi: 10.1016/j.semcancer.2022.03.011 (IF 12.1; ESI Highly Cited Paper; >100 times cited)
24. Zhang R, Yang Y, Dong W, Lin M, He J, Zhang X, et al. D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1. Proceedings of the National Academy of Sciences of the United States of America. 2022 Feb 22;119 (8):e2114851119 (IF 9.4; ESI Highly Cited Paper; >100 times cited)
25. Xu X, Mu L, Li L, Liang J, Zhang S, Jia L, et al. Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging. Science Advances. 2022 Jan 14;8(2):eabi8683 (IF 11.7)
26. Wu B, Ye Y, Xie S, Li Y, Sun X, Lv M. et al. Megakaryocytes mediate hyperglycemia-induced tumor metastasis. Cancer Research.2021 Nov 1;81(21):5506-5522 (IF 12.5)
27. Wu J, Chen Z, Wickström S, Gao J, He X, Jing X, et al. IL-33 is a novel immunosuppressor that protects cancer cells from TIL killing by a macrophage-mediated shedding mechanism. Advanced Science. 2021 Sep 5:e2101029 (IF 14.3)
28. Qiu M, Duo Y, Liang W, Yang Y, Zhang B, Xie Z, et al. Nanopoxia: Targeting cancer hypoxia by antimonene-based nanoplatform for precision cancer therapy. Advanced Functional Materials. 2021 Jul 28; doi:10.1002/adfm.202104607 (IF 18.5)
29. Huang M, Chen M, Qi M, Ye G, Pan J, Shi C, et al. Perivascular cell-derived extracellular vesicles stimulate colorectal cancer revascularization after withdrawal of antiangiogenic drugs. Journal of Extracellular Vesicles. 2021 May;10(7):e12096 (IF 15.5)
30. Sun X, He X, Zhang Y, Hosaka K, Andersson P, Wu J, et al. Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism. Gut. 2022 Jan;71(1):129-147. doi: 10.1136/gutjnl-2020-322744 Epub 2021 Feb 10 (IF 23; >100 times cited)
31. Liu Q, Xie Z, Qiu M, Shim I, Yang Y, Xie S, et al. Prodrug-loaded zirconium carbide nanosheets as a novel bio-photonic nanoplatform for effective treatment of cancer. Advanced Science. 2020 Nov 5;7(24):2001191 (IF 14.3)
32. Hosaka K, Yang Y, Seki T, Du Q, Jing X, He X, et al. Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors. Nature Communications. 2020 Jul 24;11(1):3704 (IF 14.7)
33. Ali Z, Cui D, Yang Y, Tracey-White D, Vazquez-Rodriguez G, Moosajee M, et al. Synchronized tissue-scale vasculogenesis and ubiquitous lateral sprouting underlie the unique architecture of the choriocapillaris. Developmental Biology. 2020 Jan 15;457(2):206-214 (IF 2.5)
34. Sui W, Li H, Yang Y, Jing X, Xue F, Cheng J, et al. Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis. Proceedings of the National Academy of Sciences of the United States of America. 2019 May 28;116(22):10937-10942 (IF 9.4)
35. Andersson P, Yang Y, Hosaka K, Zhang Y, Fischer C, Braun H, et al. Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis. JCI Insight. 2018 Oct 18;3(20):e122375 (IF 6.3)
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37. Feng X, Classon C, Terán G, Yang Y, Li L, Chan S, et al. Atrophy of skin-draining lymph nodes predisposes for impaired immune responses to secondary infection in mice with chronic intestinal nematode infection. PLoS Pathogens. 2018 May 17;14(5):e1007008 (IF 5.5)
38. Hosaka K, Yang Y, Nakamura M, Andersson P, Yang X, Zhang Y, et al. Dual roles of endothelial FGF-2-FGFR1-PDGF-BB and perivascular FGF-2-FGFR2-PDGFRβ signaling pathways in tumor vascular remodeling. Cell Discovery. 2018 Jan 16;4:3 (IF 13.0)
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