姓名：王勇波（副教授，研究组长）
Email：wangyongbo@fudan.edu.cn
教育背景及工作经历：
2013-今复旦大学基础医学院细胞与遗传学系青年副研究员、副教授
2012-2013德国马克斯-德尔布吕克分子医学中心(Max-Delbrück Center for Molecular Medicine)博士后
2009-2012德国马克斯-德尔布吕克分子医学中心、柏林自由大学(Free University of Berlin)生物学系博士
2006-2008上海交通大学药学院药剂学硕士
2001-2005上海交通大学药学院学士
研究领域：RNA加工调控与肿瘤生物学
RNA剪接调控具有十分重要的生物学功能，剪接异常是导致人类疾病的主要原因之一，在肿瘤发生、发展及治疗过程中发挥着关键作用。然而，剪接异常在肿瘤中的作用未被深入认识，RNA剪接与其他重要生物学过程（如mRNA翻译、细胞代谢等）的交互作用大体上未知。实验室聚焦RNA加工调控与肿瘤生物学这一新兴热点领域的关键科学问题与挑战，运用细胞、小鼠模型及临床样本，通过多组学技术与细胞、分子生物学、生物化学手段相结合，重点研究：
1、RNA剪接异常在肿瘤（特别是肺癌）中的功能、机制及临床意义；
2、RNA剪接与mRNA翻译、细胞代谢、免疫调节之间的交互作用；
3、基于RNA的疾病治疗新策略。
近年来，研究成果以通讯作者或第一作者发表在Nucleic Acids Research, EbioMedicine, EMBO Molecular Medicine等高水平学术期刊上，累计引用超过450次。主持在研国家自然科学基金面上项目、上海市自然科学基金项目等多项科研项目。
发表论文：
1. Sirui Zhang#, Yufang Bao#, Xianfeng Shen#, Yunjian Pan#, Yue Sun, Man Xiao, Kexuan Chen, Huanhuan Wei, Ji Zuo, David Saffen, Wei-Xing Zong, Yihua Sun*, Zefeng Wang*, Yongbo Wang*. RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H. EBioMedicine, 2020; 61: 103067. (IF：6.68)
2. Yongbo Wang*, Yufang Bao, Sirui Zhang, Zefeng Wang*. Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets. SCIENCE CHINA Life Sciences, 2020, 63 (4): 469–484. (IF：4.611).
3. Jia-Li Hu, He Liang, Hong Zhang, Ming-Zhu Yang, Wei Sun, Peng Zhang, Li Luo, Jian-Xiong Feng, Huajun Bai, Fang Liu, Tianpeng Zhang, Jin-Yu Yang, Qingsong Gao, Yongkang Long, Xiao-Yan Ma, Yang Chen, Qian Zhong, Bing Yu, Shuang Liao, Yongbo Wang, Yong Zhao, Mu-Sheng Zeng, Nan Cao, Jichang Wang, Wei Chen, Huang-Tian Yang, Song Gao, FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells, Nucleic Acids Research, 2020, 48 (5): 2733–2748. (IF：11.561)
4. D. A. Mugahid, T. G. Sengul, X. You, Y. Wang, L. Steil, N. Bergmann, M. H. Radke, A. Ofenbauer, M. Gesell-Salazar, A. Balogh, S. Kempa, B. Tursun, C. T. Robbins, U. Völker, W. Chen, L. Nelson & M. Gotthardt. Proteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy. Sci Rep, 2019, 9: 19976. (IF：4.122)
5. Yue Sun, Yufang Bao, Wenjian Han, Fan Song, Xianfeng Shen, Jiawei Zhao, Ji Zuo, David Saffen, Wei Chen, Zefeng Wang, Xintian You*, Yongbo Wang*. Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay. Nucleic Acids Research, 2017, 45 (14): 8524–8540. (IF：11.561)
6. Jiawei Zhao#, Yue Sun#, Yin Huang, Fan Song, Zengshu Huang, Yufang Bao, Ji Zuo, David Saffen, Zhen Shao, Wen Liu*, Yongbo Wang*. Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing. Scientific Reports, 2017, 7:40488. (IF：4.122)
7. Yingying Hu, Ling Yang, Yujie Yang, Yanyan Han, Yongbo Wang, Wen Liu, Ji Zuo. Oncogenic role of mortalin contributes to ovarian tumorigenesis by activating the MAPK–ERK pathway. Journal of Cellular and Molecular Medicine, 2016, 20(11): 2111-2121. （IF: 4.499）
8. Yongbo Wang#, Andreas Gogol-Döring#, Hao Hu, Sebastian Fröhler, Yunxia Ma, Marvin Jens, Jonas Maaskola, Yasuhiro Murakawa, Claudia Quedenau, Markus Landthaler, Vera Kalscheuer, Dagmar Wieczorek, Yang Wang, Yuhui Hu*, and Wei Chen*. Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation. EMBO Molecular Medicine, 2013, 5: 1431-1442. (IF：10.293)
9. Elisa Rodríguez-Seguel, Nancy Mah, Heike Naumann, Igor M. Pongrac, Nuria Cerdá-Esteban, Jean-Fred Fontaine, Yongbo Wang, Wei Chen, Miguel A. Andrade-Navarro, and Francesca M. Spagnoli*. Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence. Genes & Development. 2013, 27 (17): 1932-1946. (IF: 9.462)
10. Pinar Onal, Dominic Grun, Catherine Adamidi, Agnieszka Rybak, Jordi Solana, Guido Mastrobuoni, Yongbo Wang, Hans-Peter Rahn, Wei Chen, Stefan Kempa, Ulrike Ziebold, and Nikolaus Rajewsky*. Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells. EMBO Journal. 2012, 31 (12): 2755-2769. (IF: 10.557)
11.Catherine Adamidi#, Yongbo Wang#, Dominic Gruen#, Guido Mastrobuoni#, Xintian You#, Dominic Tolle, Matthias Dodt, Sebastian D. Mackowiak, Andreas Gogol-Doering, Pinar Oenal, Agnieszka Rybak, Eric Ross, Alejandro Sánchez Alvarado, Stefan Kempa*, Christoph Dieterich*, Nikolaus Rajewsky*, and Wei Chen*. De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Research. 2011, 21: 1193-1200. (co-first author, IF: 10.101)