姓名：王勇波（副教授，研究组长）
Email：wangyongbo@fudan.edu.cn
教育背景及工作经历：
2013-今复旦大学基础医学院细胞与遗传学系青年副研究员、副教授
2012-2013德国马克斯-德尔布吕克分子医学中心(Max-Delbrück Center for Molecular Medicine)博士后
2009-2012德国马克斯-德尔布吕克分子医学中心、柏林自由大学(Free University of Berlin)生物学系博士
2006-2008上海交通大学药学院药剂学硕士
2001-2005上海交通大学药学院学士
研究领域：
RNA层面的肿瘤致病机理与治疗策略
1. RNA剪接异常与癌症。运用细胞、小鼠模型及临床样本，通过多组学技术与分子细胞生物学、生物化学手段相结合，研究：1）RNA剪接异常在肿瘤（特别是肺癌）中的新功能、机制及临床意义； 2）RNA剪接与肿瘤免疫、代谢之间的交互作用；3）基于RNA剪接的疾病治疗新策略。
2. RNA可变剪接调控新机制与功能。包括：1）剪接因子的作用与表达调控机制；2）RNA剪接和mRNA翻译等基因表达调控过程的交互作用；3）单细胞RNA剪接功能与调控。
发表论文：
通讯或一作
1. Xinlu Han#, Deyu Wang#, Liao Yang, Ning Wang, Jianliang Shen, Jinghan Wang, Lei Zhang, Li Chen, Shenglan Gao, Wei-Xing Zong*, Yongbo Wang*. Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer. The Proceedings of the National Academy of Sciences, 2024, 121(13): e2319429121 (最后通讯IF 11.1)
2. Yongbo Wang*, Zefeng Wang*. Targeting dysregulated splicing factor in cancer: lessons learned from RBM10 deficiency. Journal of Molecular Cell Biology, 2024, 15(10): mjad063. (一作及共通讯IF 8.185)
3. Nan Xu#, Yunpeng Ren#, Yufang Bao#, Xianfeng Shen, Jiahui Kang, Ning Wang, Zixian Wang, Xinlu Han, Zhen Li, Ji Zuo, Gong-Hong Wei, Zefeng Wang, Wei-Xing Zong, Wen Liu, Gangcai Xie *, Yongbo Wang*. PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C. Cell Reports, 2023, 42(9):113041. (最后通讯IF 9.995)
4. Yufang Bao#, Sirui Zhang#, Xiaoyu Zhang, Yunjian Pan, Yueren Yan, Ning Wang, Yunpeng Ren, Ji Zuo, Wei-Xing Zong, Zefeng Wang*,Yongbo Wang*. RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition. Cancer Research, 2023, 83(9):1490-1502. (最后通讯IF 13.312)
5. Yueren Yan#, Yunpeng Ren#,Yufang Bao#, Yongbo Wang*. RNA splicing alterations in lung cancer pathogenesis and therapy. Cancer Pathogenesis and Therapy. 2023, 1(4): 272-283. (最后通讯)
6. Sirui Zhang#, Yufang Bao#, Xianfeng Shen#, Yunjian Pan#, Yue Sun, Man Xiao, Kexuan Chen, Huanhuan Wei, Ji Zuo, David Saffen, Wei-Xing Zong, Yihua Sun*, Zefeng Wang*, Yongbo Wang*. RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H. EBioMedicine,2020, 61: 103067. (最后通讯IF 11.205)
7. Yongbo Wang*, Yufang Bao, Sirui Zhang, Zefeng Wang*. Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets. Science China Life Sciences, 2020, 63 (4): 469–484. (一作及共通讯IF 10.372)
8. Yue Sun, Yufang Bao, Wenjian Han, Fan Song, Xianfeng Shen, Jiawei Zhao, Ji Zuo, David Saffen, Wei Chen, Zefeng Wang, Xintian You*, Yongbo Wang*. Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay. Nucleic Acids Research, 2017, 45 (14): 8524–8540. (最后通讯IF 19.160)
9. Jiawei Zhao#, Yue Sun#, Yin Huang, Fan Song, Zengshu Huang, Yufang Bao, Ji Zuo, David Saffen, Zhen Shao, Wen Liu*, Yongbo Wang*. Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing. Scientific Reports, 2017, 7:40488. (最后通讯IF 4.996)
10. Yongbo Wang#, Andreas Gogol-Döring#, Hao Hu, Sebastian Fröhler, Yunxia Ma, Marvin Jens, Jonas Maaskola, Yasuhiro Murakawa, Claudia Quedenau, Markus Landthaler, Vera Kalscheuer, Dagmar Wieczorek, Yang Wang, Yuhui Hu*, and Wei Chen*. Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation. EMBO Molecular Medicine, 2013, 5: 1431-1442. (共一IF 14.260)
11. Catherine Adamidi#, Yongbo Wang#, Dominic Gruen#, Guido Mastrobuoni#, Xintian You#, Dominic Tolle, Matthias Dodt, Sebastian D. Mackowiak, Andreas Gogol-Doering, Pinar Oenal, Agnieszka Rybak, Eric Ross, Alejandro Sánchez Alvarado, Stefan Kempa*, Christoph Dieterich*, Nikolaus Rajewsky*, and Wei Chen*. De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Research, 2011, 21: 1193-1200. (共一IF 9.438)
共同作者
1. Hyemin Lee, Ji Hoon Jung, Hyun Min Ko, Heewon Park, Allyson M Segall, Roger L Sheffmaker, Jieqiong Wang, Wesley D Frey, Nathan Pham, Yongbo Wang, Yiwei Zhang, James G Jackson, Shelya X Zeng, Hua Lu. RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5. The Proceedings of the National Academy of Sciences, 2023, 120(49): e2308292120.
2. Weiwei Dai, Jianliang Shen, Junrong Yan, Alex J Bott, Sara Maimouni, Heineken Q Daguplo, Yujue Wang, Khoosheh Khayati, Jessie Yanxiang Guo, Lanjing Zhang, Yongbo Wang, Alexander Valvezan, Wen-Xing Ding, Xin Chen, Xiaoyang Su, Shenglan Gao, Wei-Xing Zong. Glutamine synthetase limits b-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1. Journal of Clinical Investigation. 2022, 132(24): e161408 (IF 19.456)
3. Sirui Zhang, Miaowei Mao, Yuesheng Lv, Yingqun Yang, Weijing He, Yongmei Song,Yongbo Wang, Yun Yang, Muthana Al Abo, Jennifer A. Freedman, Steven R. Patierno, Yang Wang*, Zefeng Wang*. A widespread length-dependent splicing dysregulation in cancer. Science Advances. 2022, 8 (33): eabn9232. (IF 14.957)
4. Kai Hou, Jianliang Shen, Junrong Yan, Chuannan Zhai, Jingxia Zhang, Ji-An Pan, Ye Zhang, Yaping Jiang, Yongbo Wang, Richard Z Lin, Hongliang Cong*, Shenglan Gao*, Wei-Xing Zong*. Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin. EBioMedicine. 2021, 69:103456. (IF 11.205)
5. Fang Wang#, Ye Zhang#, Jianliang Shen, Bin Yang, Weiwei Dai, Junrong Yan, Sara Maimouni, Heineken Q Daguplo, Sara Coppola, Yingtang Gao, Yijun Wang, Zhi Du, Kesong Peng, Hui Liu, Qin Zhang, Fei Tang, Peng Wang, Shenglan Gao, Yongbo Wang, Wen-Xing Ding, Grace Guo, Fengmei Wang, Wei-Xing Zong*. The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway. Cellular and Molecular Gastroenterology and Hepatology. 2021, 11(5):1369-1385. (IF 8.797)
6. Jia-Li Hu, He Liang, Hong Zhang, Ming-Zhu Yang, Wei Sun, Peng Zhang, Li Luo, Jian-Xiong Feng, Huajun Bai, Fang Liu, Tianpeng Zhang, Jin-Yu Yang, Qingsong Gao, Yongkang Long, Xiao-Yan Ma, Yang Chen, Qian Zhong, Bing Yu, Shuang Liao, Yongbo Wang, Yong Zhao, Mu-Sheng Zeng, Nan Cao, Jichang Wang, Wei Chen, Huang-Tian Yang, Song Gao, FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells, Nucleic Acids Research, 2020, 48 (5): 2733–2748. (IF 19.160)
7. D. A. Mugahid, T. G. Sengul, X. You, Y. Wang, L. Steil, N. Bergmann, M. H. Radke, A. Ofenbauer, M. Gesell-Salazar, A. Balogh, S. Kempa, B. Tursun, C. T. Robbins, U. Völker, W. Chen, L. Nelson & M. Gotthardt. Proteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy. Sci Rep,2019, 9: 19976. (IF 14.260)
8. Yingying Hu, Ling Yang, Yujie Yang, Yanyan Han, Yongbo Wang, Wen Liu, Ji Zuo. Oncogenic role of mortalin contributes to ovarian tumorigenesis by activating the MAPK–ERK pathway. Journal of Cellular and Molecular Medicine, 2016, 20(11): 2111-2121. (IF 5.295)
9. Elisa Rodríguez-Seguel, Nancy Mah, Heike Naumann, Igor M. Pongrac, Nuria Cerdá-Esteban, Jean-Fred Fontaine, Yongbo Wang, Wei Chen, Miguel A. Andrade-Navarro, and Francesca M. Spagnoli*. Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence. Genes & Development. 2013, 27 (17): 1932-1946. (IF 12.890)
10. Pinar Onal, Dominic Grun, Catherine Adamidi, Agnieszka Rybak, Jordi Solana, Guido Mastrobuoni, Yongbo Wang, Hans-Peter Rahn, Wei Chen, Stefan Kempa, Ulrike Ziebold, and Nikolaus Rajewsky*. Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells. EMBO Journal. 2012, 31 (12): 2755-2769. (IF 14.012)