电子邮件：zhangsi@fudan.edu.cn  

通信地址：上海市徐汇区东安路130号240信箱

邮政编码：200032

主要研究方向：1. 血小板激活机制和抗血栓药物临床转化；2. 肿瘤早期标志物筛选和治疗靶点临床转化；3. 遗传性疾病发病和治疗靶点临床转化

张思，复旦大学基础医学院生物化学与分子生物学系教授。2012年获复旦大学博士学位；2014年复旦大学副教授；2020年复旦大学教授。2018-2019 年，美国德克萨斯医学中心，学术访问。迄今已发表SCI论文60余篇，引用1000余次，H-Index为19，近五年以第一或通讯作者在Circulation ( IF=23，2015) 、Journal of Hepatology (IF=20，2020)、 Journal of hematology & oncology (IF=11，2020)、Journal of hematology & oncology (IF=11，2021) 等期刊发表论文，论文获得Faculty Opinions推荐（F1000）。获国家自然科学基金项目资助3项，上海市自然科学基金项目资助1项，复旦大学原创探索项目1项。授权专利5项。担任Frontiers in Pharmacology客座副主编（Guest Associated Editor），国际止血与血栓协会会员，美国生物化学协会会员。

代表性论文（*通讯作者）

 1. Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy mediated DNA damage mechanism. Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen*, Ruyi Xue* and Si Zhang(通讯)*. Journal of hematology & oncology (IF=11). 2021 ，14(8) 1-19

2. Si Zhang*(通讯), Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Zhongren Ding, Yi Zhang* & Liang Hu*. SARS-CoV- 2 binds platelet ACE2 to enhance thrombosis in COVID-19. Journal of hematology & oncology, 2020，13(1), 1-22. SCI; IF=11编辑评述，Faculty Opinions推荐（F1000）  

3. Pingping Dong，Xiaoxiao Wang，Longzi Liu，Wenqing Tang，Lijie Ma，Wenjiao Zeng，Shaoyang Sun，Li Zhang，Ningping ，Zhang，Xizhong Shen，Harry L.A. Janssen，Ling Dong*，Si Zhang*（通讯）， She Chen* . Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma. Journal of Hepatology. 2020, 73(6), 1446-1459. SCI; IF=20.58  

4. Si Zhang，Shenghui Zhang, Liang Hu, Lili Zhai, Ruyi Xue, Jianqin Ye, Leilei Chen,Guanjun Cheng, Jozef Mruk， SP Kunapuli, Zhongren Ding. Nucleotide-Binding Oligomerization Domain 2 Receptor Is Expressed in Platelets and Enhances Platelet Activation and Thrombosis. Circulation, SCI; IF=23; 2015. 131(13):1160-70. 编辑评述  

5. Liu, Xijun, Ruyi Xue, Caiting Yang, Jianxin Gu, She Chen*, and Si Zhang*（通讯）. Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor–mediated suppression of the estrogen sulfotransferase SULT1E1. Journal of Biological Chemistry； 2018, 293(33): 12759-12769. SCI; IF=4.23;  

6. Yu Cai, Guanqun Huang, Lijie Ma, Ling Dong, She Chen, Xizhong Shen, Shuncai Zhang, Ruyi Xue*, Deqiang Sun*, Si Zhang*（通讯）. Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition. BBA-Molecular Cell Research; SCI; IF=4.2; (2018) 1865(2),297-308.  

7. Dalong Sun, Tiancheng Luo, Pingping Dong, Ningping Zhang, Jing Chen, Shuncai Zhang, Ling Dong*, Harry L. A. Janssen*, Si Zhang*（通讯）. M2‐polarized tumor‐associated macrophages promote epithelial‐mesenchymal transition via activation of the AKT3/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma. Journal of Cellular Biochemistry, 2020，121(4), 2828-2838. SCI; IF=4.23  

8. Dalong Sun, Tiancheng Luo, Pingping Dong, Ningping Zhang, Jing Chen, Shuncai Zhang, Longzi Liu, Ling Dong*, Si Zhang*（通讯）. CD86 /CD206 tumor-associated macrophages predict prognosis of patients with intrahepatic cholangiocarcinoma. PeerJ, 2020, 8, e8458. SCI; IF=2.37  

9. Huitong Peng, Hongyi Wu, Ge Zhang, Wei Zhang,Yifan Guo, Lin Chang, She Chen, Ruyi Xue*, and Si Zhang*（通讯）. Expression and Clinical Prognostic Value of Platelet NLRP3 in Acute Coronary Syndrome. International Journal of General Medicine, 2020，13, 791.  

10. The role of Sphingomyelin synthase 2 (SMS2) in platelet activation and its clinical significance. Yifan Guo, Lin Chang, Ge Zhang, Zhanyan Gao, Hao Lin, Yuting Zhang, Liang Hu, She Chen, Bing Fan, Si Zhang*（通讯）& Ruyi Xue*. Thrombosis Journal，2021，volume 19, Article number: 2  

11. Comprehensive Characterization of Immunological Profiles and Clinical Significance in Hepatocellular Carcinoma. Ping Tao, Liang Hong, Wenqing Tang, Qun Lu, Yanrong Zhao, Si Zhang*（通讯）, Lijie Ma* and Ruyi Xue*. Front. In Oncol, 2021