李清泉（1980-），教授，博导，复旦大学基础医学院博士。主要研究领域：肿瘤多药耐药与侵袭转移相关性、肿瘤干细胞分子生物学。代表性成果：首次提出并验证了“P-gp底物类化疗药物促进耐药乳腺癌侵袭转移”及 “化疗药物诱导药物敏感乳腺癌细胞上皮间质转化”等假说。在乳腺癌中，提出了间质型乳腺癌细胞通过旁分泌方式调控乳腺癌干细胞自我更新能力的模型；在大肠癌中，通过构建自发性肝转移和自发性肺转移模型，筛选出负责大肠癌不同靶器官转移的肿瘤干细胞亚群的分子标记物，并阐明了参与其中的相关分子机制。2009年至今发表SCI论文8篇，包括Cell stem cell, Gastroenterology，Oncogene，J Pathology，Cell Death&Differentiation等杂志。获国家青年科学基金，国家自然科学基金面上项目，复旦大学卓学计划，上海医学院研究学者、上医之星等各1项，共计科研经费130余万元。先后获2010年上海市优秀博士学位论文，2013年上海市自然科学三等奖。
主要论文：
1. Wu Z, Wei D, Gao W, Xu Y, Hu Z, Ma Z, Gao C, Zhu X, Li Q*(通讯作者). TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells. Cell stem cell. 2015;17(1):47-59.
2.Gao W, Chen L, Ma Z, Du Z, Zhao Z, Hu Z, Li Q*(通讯作者). Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential. Gastroenterology, 145(3):636-646,2013.
3.Zhuang D, Liu Y, Mao Y, Gao L, Zhang H, Luan S, Huang F, Li QQ*(通讯作者). TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells. Int J Cancer, 130(2): 309-318, 2012.
4.Li QQ (第一作者), Chen ZQ, Cao XX, Xu JD, Xu JW, Chen YY, Wang WJ, Chen Q, Tang F, Liu XP, Xu ZD. Involvement of NF-κB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial- mesenchymal transition of breast cancer cells. Cell Death Differ, 18(1): 16-25, 2011.
5.Xu JD, Cao XX, Long ZW, Liu XP, Furuya T, Xu JW, Liu XL, De Xu Z, Sasaki K, Li QQ*(通讯作者). BCL2L10 protein regulates apoptosis/proliferation through differential pathways in gastric cancer cells. J Pathol, 223(3): 400-409, 2011.
6.Li QQ (第一作者), Chen ZQ, Xu JD, Cao XX, Chen Q, Liu XP, Xu ZD. Overexpression and involvement of special AT-rich sequence binding protein 1 in multidrug resistance in human breast carcinoma cells. Cancer Sci, 101(1): 80-86, 2010.
7.Li QQ (第一作者), Xu JD, Wang WJ, Cao XX, Chen Q, Tang F, Chen ZQ, Liu XP, Xu ZD. Twist1 mediated adriamycin-induced epithelial-mesenchymal transition (EMT) relates to multidrug resistance and invasive potential in breast cancer cells. Clin Cancer Res, 15(8): 2657-65, 2009.
8.Li QQ (第一作者), Cao XX, Xu JD, Chen Q, Wang WJ, Tang F, Chen ZQ, Liu XP, Xu ZD. The role of P-glycoprotein/cellular prion protein interaction in multidrug-resistant breast cancer cells treated with paclitaxel. Cell and Mole Life Sci, 66(3): 504-15, 2009.