璩 良

  • 职    称: 青年研究员

  • 联系电话: +86-13661928826

  • 电子邮箱: quliang@fudan.edu.cn

  • 办公地点: 上海市徐汇区东安路131号复旦大学上海医学院西7号楼405室

  • 个人主页/课题组网页: 筹建中

  • 教育经历

  • 工作经历

  • 获得人才项目

  • 获得奖项

  • 研究方向

  • 科研项目

  • 代表性论著

  • 代表性专利

  • 2011.09 – 2015.07  苏州大学 医学部 生物技术(免疫工程)专业,本科

  • 2015.09 – 2020.07  北京大学 生命科学学院 生物化学与分子生物学专业,博士

  • 2020.07 – 2022.11  北京大学 生命科学学院&生物医学前沿创新中心,博士后研究(讲师)

  • 2022.11 – 至今     复旦大学 基础医学院前沿创新中心&医学系统生物学系,青年研究员

  • 2020年 “博士后创新人才支持计划”,中国人力资源与社会保障部&中国博士后管委会

  • 2020年  北京大学优秀博士学位论文,北京大学

  • 2020年  吴瑞奖,美国吴瑞纪念基金会

  • 前沿RNA技术与肿瘤免疫治疗

  • 新型基因编辑技术与疾病精准治疗

  • 2022  复旦大学引进人才科研启动资金

  • 2022  上海高水平地方高校建设人才引进项目

  • 1. Liang Qu*, Zongyi Yi*, Yong Shen*, Liangru Lin, Feng Chen, Yiyuan Xu, Zeguang Wu, Huixian Tang, Xiaoxue Zhang, Feng Tian, Chunhui Wang, Xia Xiao, Xiaojing Dong, Li Guo, Shuaiyao Lu, Chengyun Yang, Cong Tang, Yun Yang, Wenhai Yu, Junbin Wang, Yanan Zhou, Qing Huang, Ayijiang Yisimayi, Shuo Liu, Weijin Huang, Yunlong Cao, Youchun Wang, Zhuo Zhou, Xiaozhong Peng, Jianwei Wang, Xiaoliang Sunney Xie, Wensheng Wei#. Circular RNA vaccines against SARS-CoV-2 and emerging variants. Cell. 2022 May 12;185(10):1728-1744.e16.

  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971115/

  • 2. Liang Qu*, Zongyi Yi*, Shiyou Zhu*, Chunhui Wang*, Zhongzheng Cao*, Zhuo Zhou*, Pengfei Yuan*, Ying Yu, Feng Tian, Zhiheng Liu, Ying Bao, Yanxia Zhao, Wensheng Wei#. Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nature Biotechnology, 2019 Sep;37(9):1059-1069.

  • Highlighted by Nature Reviews Drug Discovery: Expanding the RNA-editing toolbox. (2019)

  • Highlighted by Nature Reviews Genetics: Expanding options for RNA based editors. (2019)

  • 入选国家“十三五”科技创新成就展:《新型基因编辑技术》(2021年)

  • Link: https://www.nature.com/articles/s41587-019-0178-z

  • 3. Zongyi Yi*, Liang Qu*, Huixian Tang*, Zhiheng Liu, Ying Liu, Feng Tian, Chunhui Wang, Xiaoxue Zhang, Ziqi Feng, Ying Yu, Pengfei Yuan, Zexuan Yi, Yanxia Zhao, Wensheng Wei#. Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo. Nature Biotechnology, 2022 Jun;40(6):946-955.

  • Highlighted by Nature Reviews Genetics: In vivo RNA base editing with circular RNAs. (2022)

  • Link: https://www.nature.com/articles/s41587-021-01180-3

  • 4. Chunsheng Dong*#, Liang Qu*, Haoyi Wang, Lin Wei, Yuanshu Dong, Sidong Xiong#. Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication. Antiviral Research. 2015 Jun;118:110-7.

  • Link: https://pubmed.ncbi.nlm.nih.gov/25843425/

  • Wensheng Wei, Liang Qu, Zongyi Yi. CIRCULAR RNA VACCINES AND METHODS OF USE THEREOF. Publication: WO2022037692A1·2022-02-24.

  • Wensheng Wei, Liang Qu, Zongyi Yi, Shiyou Zhu, Chunhui Wang, Zhongzheng Cao, Zhuo Zhou, Pengfei Yuan. Methods and Compositions for Editing RNAs. Publication: WO2020074001A1·2020-04-16.

  • Wensheng Wei, Zongyi Yi, Liang Qu, Feng Tian, Chunhui Wang, Shiyou Zhu, Zhuo Zhou. TARGETED RNA EDITING BY LEVERAGING ENDOGENOUS ADAR USING ENGINEERED RNAS. Publication: WO2021008447A1·2021-01-21.

  • Pengfei Yuan, Yanxia Zhao, Nengyin Liu, Zexuan Yi, Gangbin Tang, Wensheng Wei, Liang Qu, Zongyi Yi, Shiyou Zhu, Chunhui Wang, Zhongzheng Cao, Zhuo Zhou. METHODS AND COMPOSITIONS FOR EDITING RNAS. Publication: WO2020211780A1·2020-10-22.