RNA医学：新型RNA疫苗及RNA治疗技术开发

RNA核酸药物开发与RNA免疫治疗

新型基因编辑技术开发

Xinyue Wang, Qian Pan#, Jie Yin, Haomeng Kou, Xinyuan Liao, Chi Zhang, Yanyan Wang, Shengnan She, Ligaoyue Zhang, Wanjia Wang, Shan Qin, Xiaohong Xia, Jing Li, Fei Gao, Xinyang Li, Yong Cao, Liang Qu#. Engineered circular RNA compatible with complete nucleoside modification and rolling circle translation through a Cap-independent translation enhancer. Nature Biomedical Engineering, 2026,https://www.nature.com/articles/s41551-026-01725-4

Qian Pan#, Chi Zhang, Xinyue Wang, Jie Yin, Shengnan She, Xi Chen, Ruitao Dong, Ying Wu, Xinyuan Liao, Yanyan Wang, Hui Yan, Haomeng Kou, Wanjia Wang, Yong Cao, Hui Yang#, Liang Qu#. IVT-free, chemically synthesized protein-encoding RNA oligonucleotides (PEO) for rapid production of personalized cancer vaccines. PNAS, in press.

Wenting Guo, Huixian Tang, Zongyi Yi, Ting Zhang, Pengfei Yuan, Cuijin Wang Shuaiwei Ren, Xiwen Chang, Jiwu Ren, Wei Tang , Wenjie Sun, Jie Liu, Ying Yu, Zhiwei Lu, Hongyan Shen, Zexuan Yi, Yanxia Zhao, Gangbin Tang, Junyuan Han, Wenzhi Zhang, Haoyue Liu, Xueqing Sun, Yongjian Zhang, Cui Zhang, Yuming Wu, Ling Yang, Feng Han, Yichao Xu, Liang Qu, Xinyan Sun, Jiwen Wang, Weizhi Ji, Yongchang Chen, Wensheng Wei. Long-term reversal of Duchenne muscular dystrophy via circular arRNA-guided exon skipping in monkeys and humans. Cell, 2026, https://doi.org/10.1016/j.cell.2026.05.030.

Yanyan Wang, Liangru Lin, Xinyue Wang, Jing Li, Qian Pan, Haomeng Kou, Jie Yin, Fei Gao, Xinyuan Liao, Chenchen Zhang, Qimeng Yin, Chengzhi Zhao, Xinyang Li, Jinzhong Lin, Yichi Xu#, Min Qiu#, Dan Luo#, Liang Qu#. Synergically enhanced anti-tumor immunity of in vivo CAR by circRNA vaccine boosting. Cell Reports Medicine, 2025 Jul 18:102250. doi: 10.1016/j.xcrm.2025.102250.

Yanyan Wang, Xinyue Wang, Qian Pan, Haomeng Kou, Chi Zhang, Shengnan She, Jie Yin, Xinyuan Liao, Wanjia Wang, Ligaoyue Zhang, Huji Xu#, Tianlei Ying#, Yanling Wu#, Liang Qu#. CircRNA-based, non-integrated, in vivo panCAR-mediated B cell immune resetting in mouse models and non-human primates. bioRxiv, 2025, doi: https://doi.org/10.1101/2025.08.11.669448.

Liang Qu*, Zongyi Yi*, Yong Shen*, Liangru Lin, Feng Chen, Yiyuan Xu, Zeguang Wu, Huixian Tang, Xiaoxue Zhang, Feng Tian, Chunhui Wang, Xia Xiao, Xiaojing Dong, Li Guo, Shuaiyao Lu, Chengyun Yang, Cong Tang, Yun Yang, Wenhai Yu, Junbin Wang, Yanan Zhou, Qing Huang, Ayijiang Yisimayi, Shuo Liu, Weijin Huang, Yunlong Cao, Youchun Wang, Zhuo Zhou, Xiaozhong Peng, Jianwei Wang, Xiaoliang Sunney Xie, Wensheng Wei#. Circular RNA vaccines against SARS-CoV-2 and emerging variants. Cell, 2022 May 12;185(10):1728-1744.e16.

Liang Qu*, Zongyi Yi*, Shiyou Zhu*, Chunhui Wang*, Zhongzheng Cao*, Zhuo Zhou*, Pengfei Yuan*, Ying Yu, Feng Tian, Zhiheng Liu, Ying Bao, Yanxia Zhao, Wensheng Wei#. Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nature Biotechnology, 2019 Sep;37(9):1059-1069.

Highlighted by Nature Reviews Drug Discovery: Expanding the RNA-editing toolbox. (2019)

Highlighted by Nature Reviews Genetics: Expanding options for RNA based editors. (2019)

Zongyi Yi*, Liang Qu*, Huixian Tang*, Zhiheng Liu, Ying Liu, Feng Tian, Chunhui Wang, Xiaoxue Zhang, Ziqi Feng, Ying Yu, Pengfei Yuan, Zexuan Yi, Yanxia Zhao, Wensheng Wei#. Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo. Nature Biotechnology, 2022 Jun;40(6):946-955.

Highlighted by Nature Reviews Genetics: In vivo RNA base editing with circular RNAs. (2022)

Chunsheng Dong*#, Liang Qu*, Haoyi Wang, Lin Wei, Yuanshu Dong, Sidong Xiong#. Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication. Antiviral Research. 2015 Jun;118:110-7.