赵猛

  • 职    称:青年研究员

  • 联系电话:

  • 电子邮箱:zhaomeng@fudan.edu.cn

  • 办公地点:上海市徐汇区东安路130号复旦大学上海医学院西7号楼227室

  • 教育经历

  • 工作经历

  • 研究方向

  • 科研项目

  • 讲授课程

  • 学术兼职

  • 代表性论著

  • 代表性专利

  • 2015.10-2017.12  美国阿拉巴马大学伯明翰分校,联合培养博士研究生

  • 2011.09-2015.09  复旦大学基础医学院,硕博连读

  • 2003.08-2008.07  大连医科大学药学院,本科生

  • 2022.11-至今    复旦大学,青年研究员

  • 2020.11-2022.11  西湖大学,博士后

  • 2018.01-2020.09  美国阿拉巴马大学伯明翰分校,访问学者

  • 2008.07-2011.07  上海交通大学医学院附属第九人民医院,临床药师

  • 结合生物医学工程,基因编辑和干细胞技术开发心肌梗死治疗新手段

  • 结合类器官,CRISPR筛选和多组学技术探索先天性心肌病的治疗靶点

  • 结合荧光成像和可遗传编码的荧光探针研究心脏病发病机制

  • 2022  复旦大学引进人才科研启动资金,主持

  • 2022  上海高水平地方高校建设人才引进项目,主持

  • 2022  国自然面上项目,“长链非编码NORAD调节心梗的细胞治疗效率”,参与

  • 2021  国自然面上项目,“CRISPR筛选研究扩张型心肌病发病机制”,主持

本科生课程:

  • 病理生理学

  长期担任BioMed Research International, Frontiers in Endocrinology, International Journal of Molecular Medicine等多个SCI杂志的编辑或审稿人。

  • Nakada, Y.; Zhou, Y.; Gong, W.; Zhang, E. Y.; Skie, E.; Nguyen, T.;  Wei, Y.; Zhao, M.; Chen, W.; Sun, J.; Raza, S. N.; Chen, J. Y.; Walcott, G. P.; Garry, D. J.; Zhang, J. J., Single Nucleus Transcriptomics: Apical Resection in Newborn Pigs Extends the Time Window of Cardiomyocyte Proliferation and Myocardial Regeneration. Circulation2022, 145 (23), 1744-1747.

  • He, Y.; Li, Q.; Feng, F.; Gao, R.; Li, H.; Chu, Y.; Li, S.; Wang, Y.; Mao, R.; Ji, Z.; Hua, Y.; Shen, J.; Wang, Z.; Zhao, M.#; Yao, Q.#, Extracellular vesicles produced by human-induced pluripotent stem cell-derived endothelial cells can prevent arterial stenosis in mice via autophagy regulation. Front Cardiovasc Med 2022, 9, 922790.

  • Pan, J.; Zhao, M.; Yi, X.; Tao, J.; Li, S.; Jiang, Z.; Cheng, B.; Yuan, H.; Zhang, F., Acellular nerve grafts supplemented with induced pluripotent stem cell-derived exosomes promote peripheral nerve reconstruction and motor function recovery. Bioact Mater 2022, 15, 272-287.

  • Zhao, M.; Nakada, Y.; Wei, Y.; Bian, W.; Chu, Y.; Borovjagin, A. V.; Xie, M.; Zhu, W.; Nguyen, T.; Zhou, Y.; Serpooshan, V.; Walcott, G. P.; Zhang, J., Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction. Circulation 2021, 144 (3), 210-228.

  • Zhao, M.; Zhang, E.; Wei, Y.; Zhou, Y.; Walcott, G. P.; Zhang, J., Apical Resection Prolongs the Cell Cycle Activity and Promotes Myocardial Regeneration After Left Ventricular Injury in Neonatal Pig. Circulation 2020, 142 (9), 913-916.

  • Lou, X.; Zhao, M.; Fan, C.; Fast, V. G.; Valarmathi, M. T.; Zhu, W.; Zhang, J., N-cadherin overexpression enhances the reparative potency of human-induced pluripotent stem cell-derived cardiac myocytes in infarcted mouse hearts. Cardiovasc Res 2020, 116 (3), 671-685.

  • Zhao, M.; Fan, C.; Ernst, P. J.; Tang, Y.; Zhu, H.; Mattapally, S.; Oduk, Y.; Borovjagin, A. V.; Zhou, L.; Zhang, J.; Zhu, W., Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice. Cardiovasc Res 2019, 115 (2), 343-356.

  • Zhao, M.*; Tang, Y.*; Zhou, Y.; Zhang, J., Deciphering Role of Wnt Signalling in Cardiac Mesoderm and Cardiomyocyte Differentiation from Human iPSCs: Four-dimensional control of Wnt pathway for hiPSC-CMs differentiation. Sci Rep 2019, 9 (1), 19389.

  • Zhao, M.; Tang, Y.; Ernst, P. J.; Kahn-Krell, A.; Fan, C.; Pretorius, D.; Zhu, H.; Lou, X.; Zhou, L.; Zhang, J.; Zhu, W., Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity. J Vis Exp 2019, (149).

  • Zhu, W.*; Zhao, M.*; Mattapally, S.; Chen, S.; Zhang, J., CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle. Circ Res 2018, 122 (1), 88-96.

  • Zhu, W.; Zhang, E.; Zhao, M.; Chong, Z.; Fan, C.; Tang, Y.; Hunter, J. D., Borovjagin, A. V.; Walcott, G. P.; Chen, JY.; Qin, G.; and Zhang, J., Regenerative Potential of Neonatal Porcine Hearts. Circulation. 2018;138:2809-2816.