职 称:副教授
电子邮箱:zhengyajuan@fudan.edu.cn
办公地点:上海市徐汇区东安路130号13号楼514室
教育经历
工作经历
获得人才项目
获得奖项
研究方向
科研项目
代表性论著
代表性专利
2004.09—2009.06 河北农业大学制药工程专业 学士
2009.09—2012.03 浙江理工大学生物化学与分子生物学专业 硕士
2012.08—2014.11 中国科学院上海生物化学与细胞生物学研究所 研究实习员
2014.12—2021.11 中国科学院上海生物化学与细胞生物学研究所 助理研究员
2021.12—2025.08 中国科学院上海生物化学与细胞生物学研究所 副研究员
2025.09—至今 复旦大学基础医学院 副教授
上海市优秀学术带头人计划(19XD1404200),2019.05—2022.04,第二负责人
2023年 “中知路”长三角高价值专利运营大赛,银奖
肠道稳态失衡与炎症发生的调控机制研究
肠道菌群变化特征的解析及其诊断模型构建研究
衰老过程中免疫细胞异常浸润及其驱动肝脏等器官病变的分子机制研究
国家自然科学基金青年项目(31601129),2017.01—2019.12,主持
ShiYang Chen#, YaJuan Zheng#, XiaoJuan Ran#, Hui Du, Hua Feng, Lei Yang, YaTing Wen, ChangDong Lin, ShiHui Wang, MengWen Huang, ZhanJun Yan, DianQing Wu, HongYan Wang, GaoXiang Ge, An Zeng*, Yi Arial Zeng*, JianFeng Chen*. Integrin αEβ7+ T cells direct intestinal stem cell fate decisions via adhesion signaling. Cell Research, 2021, 31(12): 1291-1307.
YaJuan Zheng#, ZhaoYuan Fang#, Yun Xue#, Jian Zhang, JunJie Zhu, RenYuan Gao, Shun Yao, Yi Ye, ShiHui Wang, ChangDong Lin, ShiYang Chen, HsinYi Huang, Liang Hu, GeNing Jiang, HuanLong Qin, Peng Zhang*, JianFeng Chen*, HongBin Ji*. Specific gut mibrobiome signature predicts the early-stage lung cancer. Gut Microbes, 2020, 11(4): 1030-1042.
HaiLong Zhang#, YaJuan Zheng#,*, YouDong Pan#, ChangDong Lin, ShiHui Wang, ZhanJun Yan, Ling Lu, GaoXiang Ge, JinSong Li, Yi Arial Zeng, JianFeng Chen*. A mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis. BMC Biology, 2020, 18(1): 64.
HaiLong Zhang#, YaJuan Zheng#, YouDong Pan, Chang Xie, Hao Sun, YouHua Zhang, MengYa Yuan, BaoLiang Song, JianFeng Chen*. Regulatory T-cell depletion in the gut caused byintegrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity. Mucosal Immunology, 2016, 9(2): 391-400.
Yue Li#, ShiHui Wang#, YouHua Zhang#, ZhaoYuan Liu, YunZhe Zheng, Kun Zhang, ShiYang Chen, XiaoYing Lv, MengWen Huang, XingChao Pan, YaJuan Zheng, MengYa Yuan, GaoXiang Ge, Yi Arial Zeng, ChangDong Lin#,*, JianFeng Chen*. Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds. Nature Communications, 2024, 15(1):6131.
MengWen Huang#, Ling Lu#, ChangDong Lin, YaJuan Zheng, XingChao Pan, ShiHui Wang, ShiYang Chen, YouHua Zhang, ChunYe Liu, GaoXiang Ge, Yi Arial Zeng, JianFeng Chen*. LRP12 is an endogenous transmembrane inactivator of α4 integrins. Cell Reports, 2023, 42(6):112667.
Cui Liu#, JunLei Wang#, YaJuan Zheng, Yue Zhu, ZhengHang Zhou, ZhaoYuan Liu, ChangDong Lin, YaoYing Wan, YaTing Wen, ChunYe Liu, MengYa Yuan, Yi Arial Zeng, ZhanJun Yan*, GaoXiang Ge*, JianFeng Chen*. Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin 𝑎vβ3. Oncogene, 2022, 41(34): 4091-4103.
YouHua Zhang#, RuTing Xie#, HaiLong Zhang#, YaJuan Zheng, ChangDong Lin, Lei Yang, MengWen Huang, FeiFei Song, Ling Lu, MuQing Yang, Ying Liu, Qing Wei*, JiYu Li*, JianFeng Chen*. Integrin β7 inhibits colorectal cancer pathogenesis via maintaining the anti-tumor immunity. Cancer Immunology Research, 2021, 9(8):967-980.
ChangDong Lin#, YouHua Zhang#, Kun Zhang, YaJuan Zheng, Ling Lu, HaiShuang Chang, Hui Yang, YanRong Yang, YaoYing Wan, ShiHui Wang, MengYa Yuan, ZhanJun Yan, RongGuang Zhang, YongNing He, GaoXiang Ge, DianQing Wu, JianFeng Chen*. Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. Immunity, 2019, 50(1): 137-151.
Hao Sun#, Jie Liu#, YaJuan Zheng, YouDong Pan, Kun Zhang, JianFeng Chen*. Distinct chemokine signaling regulates integrin ligand specificity to dictate tissue-specific lymphocyte homing. Developmental Cell, 2014, 30(1): 61-70.
陈剑峰,季红斌,郑雅娟,方兆元。利用肠道细菌检测早期肺癌(ZL202010075225.9)