李蓓
职 称：青年副研究员
联系电话：021-54237105
电子邮箱：beili@fudan.edu.cn
办公地点：上海市徐汇区东安路130号西13号楼707室
个人主页/课题组网页：
教育经历
工作经历
研究方向
科研项目
代表性论著
2011.04 — 2017.02瑞士苏黎世大学，分子生物学系，博士
2005.09 — 2008.03同济大学，生物化学与分子生物学系，硕士
2001.09 — 2005.06扬州大学，生物技术系，本科
2022.02 — 至今复旦大学基础医学院，中西医结合学系，青年副研究员
2019.10 — 2022.01复旦大学基础医学院，神经生物学系，博士后
2010.01 — 2011.03瑞士苏黎世大学医院，神经病理学研究所，研究助理
神经退行性疾病的发病机制和诊治方法
全自动高通量筛选在疾病研究和药物开发中的应用
2022，国家自然科学基金青年基金项目，国家自然科学基金委员会，主持
2021，中国博士后科学基金面上项目资助一等，中国博士后科学基金会，主持
Bei Li, Meiling Chen, Adriano Aguzzi, Caihong Zhu. The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis. Journal of Molecular Medicine (Berlin, Germany). 2021; 99(6), 877–887.
Bei Li#, Meiling Chen#, Caihong Zhu.Neuroinflammation in Prion Disease. International Journal of Molecular Sciences. 2021;22(4), 2196.
Caihong Zhu#, Bei Li#, Karl Frontzek, Yingjun Liu, Adriano Aguzzi. SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. The Journal of Experimental Medicine. 2019; 216(4), 743–756.
Marian Hruska-Plochan#, Bei Li#, Diego Kyburz, Jan Krützfeld, Ulf Landmesser, Adriano Aguzzi, Magdalini Polymenidou. New and emerging roles of small RNAs in neurodegeneration, muscle, cardiovascular and inflammatory diseases. Swiss Medical Weekly. 2015;145, w14192.
Caihong Zhu, Zhihao Li, Bei Li, Manuela Pfammatter, Simone Hornemann, Adriano Aguzzi. Unaltered prion disease in mice lacking developmental endothelial locus-1. Neurobiology of Aging. 2019; 76, 208–213.
Uli S Herrmann, Anne K Schütz, Hamid Shirani, Danzhi Huang, Dino Saban, Mario Nuvolone, Bei Li, Boris Ballmer, Andreas K O Åslund, Jeffrey J Mason, Elisabeth Rushing, Herbert Budka, Sofie Nyström, Per Hammarström, Anja Böckmann, Amedeo Caflisch, Beat H Meier, K Peter R Nilsson, Simone Hornemann, Adriano Aguzzi. Structure-based drug design identifies polythiophenes as antiprion compounds. Science Translational Medicine. 2015; 7(299), 299ra123.
Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzzi. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of Aging. 2015; 36(5), 1994–2003.
Uli S Herrmann, Tiziana Sonati, Jeppe Falsig, Regina R Reimann, Paolo Dametto, Tracy O'Connor, Bei Li, Agnes Lau, Simone Hornemann, Silvia Sorce, Uli Wagner, Despina Sanoudou, Adriano Aguzzi. Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. PLoS Pathogens. 2015; 11(2), e1004662.
Tiziana Sonati, Regina R Reimann, Jeppe Falsig, Pravas Kumar Baral, Tracy O'Connor, Simone Hornemann, Sine Yaganoglu, Bei Li, Uli S Herrmann, Barbara Wieland, Mridula Swayampakula, Muhammad Hafizur Rahman, Dipankar Das, Nat Kav, Roland Riek, Pawel P Liberski, Michael N G James, Adriano Aguzzi. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature. 2013; 501(7465), 102–106.
Jeppe Falsig, Tiziana Sonati, Uli S Herrmann, Dino Saban, Bei Li, Karina Arroyo, Boris Ballmer, Pawel P Liberski, Adriano Aguzzi. Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures. PLoS Pathogens. 2012; 8(11), e1002985.
