• 方向一：肾小球壁层上皮细胞活化及分化

• 方向二：肾小球足细胞损伤

• 方向三：糖尿病肾病

• 2021年上海市中西医结合学会器官纤维化专委会

• 2016-2019 上海市医学会肾脏病专科分会青年委员

• Liu Xueguang, Renal Pathology of Nephrotic Syndrome in Chinese Children, 13th 2015 Korea-China -Japan Pediatric Nephrology Seminar 2015, Seoul, South Korea, 9-10 May 2015

目前主要从事2方面研究工作：1.通过建立基因敲除动物模型，观察Notch3在局灶节段性肾小球硬化发生发展中对壁层上皮细胞活化及分化的作用及分子机制；初步发现足细胞中Notch3信号传导与PKA-CREB信号通路存在相互拮抗的作用；2.探讨乙酰肝素酶（HPSE）在糖尿病肾病中的作用机制，初步发现HPSE可通过影响肾小球内皮细胞表型变化而参与糖尿病肾病损伤。

发表论文：

1. Chang K,Xue R,Zhao M, Zhao Y, Yu W, Zhao Z, Liu X. EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling. Exp Cell Res 2021 Sep 07

2. Xiaofan Cai, Yueyi Deng, Xueguang Liu, Zhigang Zhang, and Zhonghua Zhao. Treatment of IgA-κcrystalline light chain proximal tubulopathy with traditional Chinese medicine. Clinical nephrology, 2019, 92(3): 159-161.

3. Chang K, Yuan C, Liu X. A New RBPs-Related Signature Predicts the Prognosis of Colon Adenocarcinoma Patients. Front Oncol 2021;11

4. Kaili Chang, Chong Yuan, Xueguang Liu*. Ferroptosis-related gene signature accurately predicts survival outcomes in patients with clear-cell renal cell carcinoma. Frontiers in Oncology. 2021;11 doi.org/10.3389/fonc.2021.649347

5. Nan Dong, Lixia Meng, Ruqun Xue, Meng Yu, Zhonghua Zhao, Xueguang Liu. Adrenomedullin ameliorates podocyte injury induced by puromycin aminonucleoside in vitro and in vivo through modulation of Rho GTPases. Int Urol Nephrol (2017) 49:1489–1506.

6. MingHua Shang, Nan Zhu, Jing Hao, Ling Wang, ZhiYan He, Man Yang, WeiJie Yuan, XueGuang Liu. Membranous Nephropathy Associated with Tuberculosis.  Chinese Medical Journal, 2016, 129(5): 622-623.

7. Xueguang Liu, Hong Liu, Zhonghua Zhao, Zhigang Zhang, Xiaoqiang Ding. Fibrillary glomerulonephritis complicated by membranous nephropathy in a patient with tuberculosis. Int Urol Nephrol (2013) 45:1501–1504.

8. 肖川, 董楠, 赵仲华, 刘学光. Adrenomedullin通过调控Rho GTPases促进足细胞细胞间接触的形成. 中华肾脏病杂志, 2016, 2016 Vol. 32 (4): 284-291 (通讯作者)

专著：

1. 参编基础医学本科核心课程系列教材《病理学》和《病理学实验教程》，《现代组织化学原理与技术》