He, X.Y., Hua, Y., Li, Q., Zhu, W., Pan, Y., Yang, Y.L., Li, X.Y., Wu, M.X., Wang, J.Y., Gan, X.Q.* FNDC5/irisin facilitates muscle−adipose−bone connectivity through ubiquitination- dependent activation of runt-related transcriptional factors RUNX1/2. The Journal of Biological Chemistry. 298 (3): 1-17, 2022.
Hua, Y., Yang, Y.L., Li, Q., He, X.Y., Zhu, W., Wang, J.Y., Gan. X.Q.* Oligomerization of Frizzled and low-density lipoprotein receptor-related protein 5/6 initiates intracellular signaling for the canonical WNT/β-catenin pathway. The Journal of Biological Chemistry. 293 (51): 19710-19724, 2018. ( > 33 citations)
Li, Q., Hua, Y., Yang, Y.L., He, X.Y., Zhu, W., Wang, J.Y., Gan. X.Q.* T Cell Factor 7 (TCF7)/TCF1 feedback controls osteocalcin signaling in brown adipocytes independent of Wnt/b-catenin pathway. Molecular and Cellular Biology. 38 (7), e00562-17, 2018. (selected as ‘spotlight’, > 14 citations)
Zhu, W., He, X.Y., Hua, Y., Li, Q., Wang, J.Y., Gan. X.Q.* The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation. The Journal of Biological Chemistry. 292 (27): 11178-11188, 2017. ( > 32 citations)
Gan. X.Q.,* Wang, J.Y., Wang, C., Sommer, E., Kozasa, T., Srinivasula, S., Alessi, D., Offermanns, S., Simon, M.I., Wu, D.Q. PRR5L degradation promotes mTORC2-mediated PKC- phosphorylation and cell migration downstream of G12. Nature Cell Biology. 14 (7): 686-696, 2012. ( > 145 citations)
Gan. X.Q.,* Wang, J.Y., Su, B., Wu, D.Q. Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3, 4, 5-trisphophate. The Journal of Biological Chemistry. 286 (13): 10998-11002, 2011. ( > 235 citations)
Gan. X.Q.,* Wang, J.Y., Xi, Y., Wu, Z.L., Li, Y.P., Li, L. Nuclear Dishevelled, c-Jun, -Catenin and TCF form a complex leading to stabilization of -catenin/TCF interaction. Journal of Cell Biology. 180 (6): 1087-1100, 2008. ( > 245 citations)
