李倩

  • 职    称:青年研究员

  • 电    话:13262760779

  • 电子邮箱:qianli_fd@fudan.edu.cn

  • 办公地点:上海市徐汇区东安路130号9号楼

  • 教育经历

  • 工作经历

  • 研究方向

  • 科研项目

  • 讲授课程

  • 代表性论著

  • 2003.09—2008.07  郑州大学河南医学院 本科

  • 2008.09—2011.07  上海交通大学眼科学 硕士

  • 2012.07—2020.03  瑞典卡罗林斯卡医学院 博士

  • 2020.03—2021.03 瑞典卡罗林斯卡医学院 博士后

  • 2022.01—至今     复旦大学基础医学院 青年研究员

  • 侧重于将临床数据与人体脂肪组织实验室研究相结合的方式,探索肥胖和代谢失衡发展过程中的脂肪组织细胞学改变,与全身代谢稳态的关联,以及引起代谢失衡的机制。

  • 通过探索临床用药及手术治疗等干预手段对脂肪组织的功能影响,开发靶向性逆转肥胖和代谢紊乱的新治疗方法。

  • 复旦大学引进人才科研启动基金    2022- 2025   负责人

  • 系统解剖学、局部解解剖学

  1. Qian Li*, Carolina E Hagberg*, Helena Silva Cascales , Shuai Lang , Mervi T Hyvönen, Firoozeh Salehzadeh, Ping Chen, Ida Alexandersson, Eleni Terezaki, Matthew J Harms, Maria Kutschke, Nahida Arifen, Niels Krämer, Myriam Aouadi, Carole Knibbe, Jeremie Boucher, Anders Thorell, Kirsty L Spalding. Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce. Nat Med. 2021 Nov;27(11):1941-1953.

  2. Jesper Bäckdahl, Lovisa Franze´n, Lucas Massier, Qian Li, Jutta Jalkanen, Hui Gao, Alma Andersson, Nayanika Bhalla, Anders Thorell, Mikael Rydén, Patrik L Ståhl, Niklas Mejhert. Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin. Cell Metab. 2021 Nov 2;33(11):2301.

  3. Smith U, Li Q, Rydén M, Spalding KL. Cellular senescence and its role in white adipose tissue. Int J Obes (Lond). 2021 May;45(5):934-943.

  4. Harms MJ, Li Q, Lee S, Zhang C, Kull B, Hallen S, Thorell A, Alexandersson I, Hagberg CE, Spalding KL, Boucher J. Mature human white adipocytes cultured under membranes maintain identity, function, and can transdifferentiate into brown-like adipocytes. Cell Rep. 2019 Apr 2;27(1):213-225

  5. Hagberg CE, Li Q, Kutschke M, Bhowmick D, Kiss E, Shabalina IG, Harms MJ, Shilkova O, Kozina V, Nedergaard J, Boucher J, Thorell A, Spalding KL. Flow cytometry of mouse and human adipocytes for the analysis of browning and cellular heterogeneity. Cell Rep. 2018 Sep 4;24(10):2746-2756.

  6. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Transforming growth factor-β3 regulates adipocyte number in subcutaneous white adipose tissue. Cell Rep, 2018 Oct; 25(3):551-560.

  7. Zheng Z, Chen H, Wang H, Ke B, Zheng B, Li Q, Li P, Su L, Gu Q, Xu X. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. Diabetes, 2010 Sep; 59(9):2315-25.

  8. Zhao H, Jin H, Li Q, Gu Q, Zheng Z, Wu H, Ye S, Sun X, Xu X, Ho PC. Inhibition of pathologic retinal neovascularization by a small peptide derived from human apolipoprotein(a). Invest Ophthalmol Vis Sci, 2009 Nov; 50(11):5384-95.