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Pathophysiology For MED130214.01
Instructor: Sifeng Chen, Ning Sun, Dan Meng, Meng Xiang, Xiaobo Li, Xinhong Wang, Chao Lu, Yanxia Ning, Chen Xu, Lei Lv
Classroom Location: F2608
Days & Hours: Tuesday, 8:55-11:35 AM
Office: West Build#7, Room 214, Shanghai Medical College
Office Phone: 021-54237623
Mobile Phone:
Office Hours: by appointment
Email: chen1216@fudan.edu.cn
Textbook:
Textbook of Pathophysiology by Wang et al., People’s Health Press, 2007
Supplementary Material:
Contemporary Pathophysiology by Xianshou Kong, Shanghai Medical University Press, 1998
Course Objectives:
Pathophysiology is a branch of medical sciences that combines physiology and pathology to elucidate the etiology and pathogenesis of disease. It concerns the occurrence, development and outcome of disease to clarify the essence of disease, and provides experimental and theoretical basis for clinical diagnosis, treatment and prevention. Thus, it is believed to serve a bridge between basic medical science and clinical science, play an important role in the medical education system. Pathophysiology is mainly composed of four parts: a brief introduction of disease, fundamental common pathological processes, organic pathophysiology and cellular and molecular pathophysiology. Based on the training guidance for the students majored in clinical medicine and other related clinical medicine, students will be expected to obtain the following knowledge and skill after taking this course.
1. Basic theory and knowledge
1）Master the underlying mechanisms by which disease occurs and the resultant functional and metabolic alternations within the body.
2）Be familiar with the causes and conditions of disease.
3）Understand the pathophysiological basis for clinical diagnosis, treatment and prevention.
2. General capability and skill
1）Self-learning ability: Points will be explained and stressed in the class. Further reading will be instructed.
2）Skills of problem-solving and comprehensive analytical ability: Questions in actual clinical cases will be discussed.
3）Speciality English terms.
3. Innovative ability
Course Schedule:
Week 1 9/11 Concept of Pathophyisology
Week 2 9/18 Disorders of Water and Sodium Metabolism
Week 3 9/25 Disorders of Potassium Metabolism
Week 4 10/2 Holiday
Week 5 10/9 Stress and Related Disease
Week 6 10/16 Fever
Week 7 10/23 Hypoxia
Week 8 10/30 Disseminated Intravascular Coagulation
Week 9 11/6 Shock
Week 10 11/13 Ischemia-Reperfusion injury
Week 11 11/20 Acid-Base Balance and Disturbances
Week 12 11/27 Heart Failure
Week 13 12/4 Renal Failure
Week 14 12/11 Respiratory Failure
Week 15 12/18 Hepatic Failure
Week 16 12/25 Case Study
Week 17 1/1 Holiday
Week 18 1/9 Final Exam
Course Requirements:
Pathophysiology is a bridge between clinical medicine and basic medicine. The present course will focus on the following contents. Firstly, the concept of disease-etiology, pathogenesis and outcome-are explained. Secondly, several fundamental pathological processes, for example, fluid and electrolyte balance and imbalance, acid-base balance and distribution, hypoxia, fever, apoptosis, stress, DIC, shock and ischemia-reperfusion injury will be addressed. Finally, dysfunctions or failure of vital organs, including heart, lung, kidney, liver and brain will be described. This course requires students to master the mechanism of every basic fundamental process, the basic pathogenesis of disease in each part.
Grading:
Contribution to Class Discussion 15%
Case Study & Oral Presentation 25%
Final Exam 60%
Recommended Reading:
Pathophysiology: The Biologic Basis for Disease in Adults and Children, 7e. Dec 27, 2013，by Kathryn L. McCance and Sue E. Huethe
Porth's Pathophysiology: Concepts of Altered Health States. Oct 4, 2013, by Sheila Grossman and Carol Mattson Porth
Pathophysiology of Disease: An Introduction to Clinical Medicine 7/E. Apr 18, 2014, by Gary D. Hammer and Stephen J. McPhee
Gould's Pathophysiology for the Health Professions, 5e. Jan 1, 2014, by Karin C. VanMeter PhD and Robert J Hubert BS
