姓名：赵猛
职称：青年研究员
办公地点：上海市徐汇区东安路130号复旦大学上海医学院西7号楼227室
教育经历
2015.10-2017.12 美国阿拉巴马大学伯明翰分校，联合培养博士研究生
2011.09-2015.09 复旦大学基础医学院，硕博连读
2003.08-2008.07 大连医科大学药学院，本科生
工作经历
2022.11-至今 复旦大学，青年研究员
2020.11-2022.11 西湖大学，博士后
2018.01-2020.09 美国阿拉巴马大学伯明翰分校，访问学者
2008.07-2011.07 上海交通大学医学院附属第九人民医院，临床药师
研究方向
1.结合生物医学工程，基因编辑和干细胞技术开发心肌梗死治疗新手段
2.结合类器官，CRISPR筛选和多组学技术探索先天性心肌病的治疗靶点
3.结合荧光成像和可遗传编码的荧光探针研究心脏病发病机制
科研项目
2023 国自然优秀青年基金，“遗传性心肌病治疗靶点开发”，主持
2022 复旦大学引进人才科研启动资金，主持
2022 上海高水平地方高校建设人才引进项目，主持
2022 国自然面上项目，“长链非编码NORAD调节心梗的细胞治疗效率”，参与
2021 国自然面上项目，“CRISPR筛选研究扩张型心肌病发病机制”，主持
课程讲授
本科生课程：病理生理学
研究生课程：实用生物医学实验技术、人体病理生理学、高级病理生理学
学术兼职
长期担任BioMed Research International, Frontiers in Endocrinology, International Journal of Molecular Medicine等多个SCI杂志的编辑或审稿人。
代表性论著
1. Nakada, Y.; Zhou, Y.; Gong, W.; Zhang, E. Y.; Skie, E.; Nguyen, T.; Wei, Y.; Zhao, M.; Chen, W.; Sun, J.; Raza, S. N.; Chen, J. Y.; Walcott, G. P.; Garry, D. J.; Zhang, J. J., Single Nucleus Transcriptomics: Apical Resection in Newborn Pigs Extends the Time Window of Cardiomyocyte Proliferation and Myocardial Regeneration. Circulation 2022, 145 (23), 1744-1747.
2. He, Y.; Li, Q.; Feng, F.; Gao, R.; Li, H.; Chu, Y.; Li, S.; Wang, Y.; Mao, R.; Ji, Z.; Hua, Y.; Shen, J.; Wang, Z.; Zhao, M.#; Yao, Q.#, Extracellular vesicles produced by human-induced pluripotent stem cell-derived endothelial cells can prevent arterial stenosis in mice via autophagy regulation. Front Cardiovasc Med 2022, 9, 922790.
3. Pan, J.; Zhao, M.; Yi, X.; Tao, J.; Li, S.; Jiang, Z.; Cheng, B.; Yuan, H.; Zhang, F., Acellular nerve grafts supplemented with induced pluripotent stem cell-derived exosomes promote peripheral nerve reconstruction and motor function recovery. Bioact Mater 2022, 15, 272-287.
4. Zhao, M.; Nakada, Y.; Wei, Y.; Bian, W.; Chu, Y.; Borovjagin, A. V.; Xie, M.; Zhu, W.; Nguyen, T.; Zhou, Y.; Serpooshan, V.; Walcott, G. P.; Zhang, J., Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction. Circulation 2021, 144 (3), 210-228.
5. Zhao, M.; Zhang, E.; Wei, Y.; Zhou, Y.; Walcott, G. P.; Zhang, J., Apical Resection Prolongs the Cell Cycle Activity and Promotes Myocardial Regeneration After Left Ventricular Injury in Neonatal Pig. Circulation 2020, 142 (9), 913-916.
6. Lou, X.; Zhao, M.; Fan, C.; Fast, V. G.; Valarmathi, M. T.; Zhu, W.; Zhang, J., N-cadherin overexpression enhances the reparative potency of human-induced pluripotent stem cell-derived cardiac myocytes in infarcted mouse hearts. Cardiovasc Res 2020, 116 (3), 671-685.
7. Zhao, M.; Fan, C.; Ernst, P. J.; Tang, Y.; Zhu, H.; Mattapally, S.; Oduk, Y.; Borovjagin, A. V.; Zhou, L.; Zhang, J.; Zhu, W., Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice. Cardiovasc Res 2019, 115 (2), 343-356.
8. Zhao, M.*; Tang, Y.*; Zhou, Y.; Zhang, J., Deciphering Role of Wnt Signalling in Cardiac Mesoderm and Cardiomyocyte Differentiation from Human iPSCs: Four-dimensional control of Wnt pathway for hiPSC-CMs differentiation. Sci Rep 2019, 9 (1), 19389.
9. Zhao, M.; Tang, Y.; Ernst, P. J.; Kahn-Krell, A.; Fan, C.; Pretorius, D.; Zhu, H.; Lou, X.; Zhou, L.; Zhang, J.; Zhu, W., Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity. J Vis Exp 2019, (149).
10. Zhu, W.*; Zhao, M.*; Mattapally, S.; Chen, S.; Zhang, J., CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle. Circ Res 2018, 122 (1), 88-96.
11. Zhu, W.; Zhang, E.; Zhao, M.; Chong, Z.; Fan, C.; Tang, Y.; Hunter, J. D., Borovjagin, A. V.; Walcott, G. P.; Chen, JY.; Qin, G.; and Zhang, J., Regenerative Potential of Neonatal Porcine Hearts. Circulation. 2018;138:2809-2816.