姓 名:梁倩倩
职 称:青年副研究员
电 话:021-54237055
电子邮箱:qianqianliang @fudan.edu.cn
办公地点:上海市徐汇区东安路130号7号楼210
教育经历:
2008.09—2013.06 北京生命科学研究所生物化学与分子生物学博士研究生
工作经历:
2013.06—2014.08 中科院生物物理研究所助理研究员
2014.09—2016.07 复旦大学基础医学院博士后
2016.08—至今 复旦大学基础医学院青年副研究员
获得人才项目:
2018,青年人才托举工程,中国科协
研究方向:
1.心脏发育机制
2.心脏疾病发生机制
科研项目:
2016, 国家自然科学基金委员会青年科学基金项目,“转录因子Mesp1结合组蛋白甲基转移酶Ezh2调控人类多能干细胞心血管定向分化的分子机制”,主持
2018,中国科协青年人才托举工程,主持
2016,复旦大学引进人才科研启动经费,“Ezh1与Ezh2调控人类多能干细胞心血管定向分化的机制”,主持
2016,中国博士后科学基金会第九批特别资助,“Ezh1与Ezh2调控人类多能干细胞心血管定向分化的机制”,主持
2017,上海市科委优秀学术带头人,“基于新型高效的扩张型/肥厚型心肌病细胞模型的高通量天然药物筛选”,第二责任人
2016,科技部国家重点研发计划重点专项,“1型糖尿病的遗传与免疫发病机制和相关防控技术研究”,子课题骨干
课程讲授:
本科生课程:
病理生理学、疾病机制、功能学科综合实验
研究生课程:
高级病理生理学,实用生物医学实验技术
学术兼职:
Frontiers in Cell and Developmental Biology杂志Review Editor
代表性论著:
1. Bin Li(#), Yongkun Zhan(#), Qianqian Liang(#), Chen Xu, Xinyan Zhou, Huanhuan Cai, Yufan Zheng, Yifan Guo, Lei Wang, Wenqing Qiu, Baiping Cui, Chao Lu, Ruizhe Qian, Ping Zhou, Haiyan Chen, Yun Liu, Sifeng Chen, Xiaobo Li, Ning Sun(*). Isogenic Human Pluripotent Stem Cell Disease Models Reveal ABRA Deficiency Underlies cTnT Mutation-induced Familial Dilated Cardiomyopathy, Protein & Cell, 2022, 13(1):65–71.
2. Xiuya Li(#), Fei Gao(#), Xiaochen Wang(#), Qianqian Liang(#), Aobing Bai, Zhuo Liu, Xinyun Chen, Ermin Li, Sifeng Chen, Chao Lu, Ruizhe Qian, Ning Sun(*), Ping Liang(*), Chen Xu(*). E2A ablation enhances proportion of nodal-like cardiomyocytes in cardiac-specific differentiation of human embryonic stem cells, EBioMedicine, 2021, 71, 103575.
3. Bin Li(#), Yifan Guo, Yongkun Zhan, Xinyan Zhou, Yongbo Li, Chao Zhao, Ning Sun(*), Chen Xu(*) and Qianqian Liang(*). Cardiac Overexpression of XIN Prevents Dilated Cardiomyopathy Caused by TNNT2 ΔK210 Mutation, Frontiers in Cell and Developmental Biology, 2021, 9: 691749.
4. Huanhuan Cai(#), Bin Li(#), Aobing Bai(#), Jie Huang, Yongkun Zhan, Ning Sun, Qianqian Liang(*), Chen Xu(*). Establishing a new human hypertrophic cardiomyopathy-specific model using human embryonic stem cells, Experimental Cell Research, 2020 Feb 1;387(1):111736.
5. Qianqian Liang(#), Chen Xu(#), Xinyun Chen, Xiuya Li, Chao Lu, Ping Zhou, Lianhua Yin, Ruizhe Qian, Sifeng Chen, Zhendong Ling(*) and Ning Sun(*). The Roles of Mesp Family Proteins: Functional Diversity and Redundancy in Differentiation of Pluripotent Stem Cells and Mammalian Mesodermal Development, Protein & Cell, 2015 Aug, 6 (8): 553-561
6. Bin Guo(#), Qianqian Liang(#), Lin Li, Zhe Hu, Fan Wu, Peipei Zhang, Yongfen Ma, Bin Zhao, Attila L. Kovács, Zhiyuan Zhang, Du Feng, She Chen and Hong Zhang(*). O-GlcNAc-modification of SNAP-29 Regulates Autophagosome Maturation, Nature Cell Biology, 2014 Dec, 16(12): 1215-1226 (Commented in the same issue of Nature Cell Biology by Noboru Mizushima)
7. Qianqian Liang(#), Peiguo Yang, E Tian, Jinghua Han, Hong Zhang(*). The C. elegans ATG101 Homolog EPG-9 Directly Interacts with EPG-1/Atg13 and is Essential for Autophagy, Autophagy, 2012 Oct, 8(10): 1426-1433
8. Bin Guo(#), Xinxin Huang(#), Peipei Zhang, Linxiang Qi, Qianqian Liang, Xuebo Zhang, Jie Huang, Bin Fang, Wenru Hou, Jinghua Han, Hong Zhang(*). Genome-wide Screen Identifies Signaling Pathways that Regulate Autophagy during Caenorhabditis elegans Development, EMBO Reports, 2014, 15(6): 705-713