支秀玲 副教授

         电 话：021-54237651

         电子邮箱：zhixiuling@fudan.edu.cn

         办公地点：东安路130号7号楼208

教育经历：

(1)2004-09 至 2009-06, 复旦大学, 病理学与病理生理学, 博士

(2)1993-09 至 1998-06, 滨州医学院, 临床医学, 学士

工作经历：

(1)2015-12 至 今, 复旦大学, 基础医学院生理与病理生理学系, 副教授

(2) 2012-02 至 2014-02, 美国乔治城大学Georgetown University，博士后

(3)2009-07 至 2015-11, 复旦大学, 基础医学院分子生物学实验室, 讲师

(4)1998-07 至 2004-07, 滨州医学院, 临床医学系生物化学教研室, 讲师

研究方向：

1.肝脏病理生理学及胰岛素抵抗发生机制

2.心血管疾病病理生理学

科研项目：

2022，上海市自然科学基金面上项目，“肝细胞SPTBN1抑制肝星状细胞活化减轻肝纤维化的机制研究”，主持

2015，国家自然科学基金面上项目，“SPTBN1缺失介导肝干细胞增殖与恶性转化的作用及其分子机制研究”，主持

2014，上海市自然科学基金面上项目，“βII-spectrin抑制肝癌发生发展的机制：TGF-β与Wnt的对话”，主持

2013，国家自然科学基金青年项目，“类胰蛋白酶活化内皮祖细胞在乳腺癌血管新生中的作用及机制”，主持

课程讲授：

本科生课程：

病理生理学、疾病机制、功能学科综合实验I、功能学科综合实验II、基于疾病的多学科教学Ⅲ、基于疾病的多学科教学Ⅱ

研究生课程：

实用生物医学实验技术、高级病理生理学、人体病理生理学

学术兼职：

• 2021.11-今 中国病理生理学会肿瘤专业委员会 委员

• 2015.11-2021.11 中国病理生理学会肿瘤专业委员会 青年委员

代表性论著：

1. Chen, Shuyi; Wu, Huijie; Wang, Zhengyang; Jia, Mengping; Guo, Jieyu; Jin, Jiayu; Li, Xiaobo; Meng, Dan; Lin, Ling; He, Aiwu R.; Zhou, Ping; Zhi, Xiuling; Loss of SPTBN1 suppresses autophagy via SETD7-mediated YAP methylation in hepatocellular carcinoma initiation and development, Cell Mol Gastroenterol Hepatol, 2022,13:949–973. 末位通讯，影响因子9.225

2. Wu, Huijie; Chen, Shuyi; Liu, Chenyang; Li, Jiajia; Wei, Xiangxiang; Jia, Mengping; Guo, Jieyu; Jin, Jiayu; Meng, Dan; Zhi, Xiuling; SPTBN1 inhibits growth and epithelial-mesenchymal transition in breast cancer by downregulating miR-21,Eur J Pharmacol,2021,909:174401. 唯一通讯，影响因子4.432

3. Lin, Ling; Chen, Shuyi; Wang, H; Gao, Bin; Kallakury, Bhaskar; Bhuvaneshwar, Krithika; Cahn, Katherine; Gusev, Yuriy; Wang, Xue; Wu, Yunan; Marshall, John L.; Zhi, Xiuling; He, Aiwu R.; SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma, Theranostics,2021,11(9):4232-4250. 共同通讯，影响因子11.556

4. Chen, Shuyi; Li, Jiajia; Zhou, Ping; Zhi, Xiuling; SPTBN1 and cancer, which links? J Cell Physiol,2020,235:17-25. 唯一通讯，影响因子6.384

5. Han, Wenyan; Zhang, Yiqun; Niu, Cong; Guo, Jieyu; Li, Jiajia; Wei, Xiangxiang; Jia, Mengping; Zhi, Xiuling; Yao, Liangqing; Meng, Dan; BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition, Cancer Lett,2019,445:45-56. 共同通讯，影响因子8.697

6. Chen, Liang; Gao, Beiyao; Zhang, Yadong; Lu, Hanyu; Li, Xiaobo; Pan, Luanfeng; Yin, Lianhua; Zhi, Xiuling; PAR2 promotes M1 macrophage polarization and inflammation via FOXO1 pathway,J Cell Biochem,2019, 120:9799-9809. 末位通讯，影响因子4.429

7. Qiu, Yanyan; Sui, Xianxian; Zhan, Yongkun; Xu, Chen; Li, Xiaobo; Ning, Yanxia; Zhi, Xiuling; Yin, Lianhua; Steroidogenic acute regulatory protein (StAR) overexpression attenuates HFD-induced hepatic steatosis and insulin resistance, Biochim Biophys Acta Mol Basis Dis, 2017,1863:978-990. 共通通讯，影响因子5.187

8. Qiu, Yanyan; Sui, Xianxian; Cao, Shengxuan; Li, Xiaobo; Ning, Yanxia; Wang, Songmei; Yin, Lianhua; Zhi, Xiuling; Steroidogenic acute regulatory protein (StAR) overexpression reduces inflammation and insulin resistance in obese mice, J Cell Biochem,2017, 118:3932-3942. 末位通讯，影响因子4.429

9. Zhi, Xiuling; Lin, Ling; Yang, Shaoxian; Bhuvaneshwar, Krithika; Wang, Hongkun; Gusev, Yuriy; Lee, Mi-Hye; Kallakury, Bhaskar; Shivapurkar, Narayan; Cahn, Katherine; Tian, Xuefei; Marshall, John L.; Byers, Stephen W.; He, Aiwu R.;betaII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin, Hepatology,2015, 61:598-612. 唯一一作，影响因子17.425