Nikolaos Giannareas1#, Qin Zhang1#, Xiayun Yang1#, Rong Na2#, Yijun Tian3, Yuehong Yang1, Xiaohao Ruan4, Da Huang4, Xiaoqun Yang5, Chaofu Wang5, Peng Zhang6, Aki Manninen1, Liang Wang4, Gong-Hong Wei*. Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG. Nature Communications. accepted

Zhang N, Huang D, Jiang G, Chen S, Ruan X, Chen H, Huang J, Liu A, Zhang W, Lin X, Wu Y, Zhang Q, Li J, Tsu JH*, Wei GH*, Na R*. Genome-Wide 3'-UTR Single Nucleotide Polymorphism Association Study Identifies Significant Prostate Cancer Risk-Associated Functional Loci at 8p21.2 in Chinese Population. Adv Sci(Weinh). 2022 Aug;9(23):e2201420.

Chen Y, Zhang P, Liao J, Cheng J, Zhang Q, Li T, Zhang H, Jiang Y, Zhang F, Zeng Y, Mo L, Yan H, Liu D, Zhang Q, Zou C*, Wei GH*, Mo Z*. Single-cell transcriptomics reveals cell type diversity of human prostate. J Genet Genomics. 2022 Apr 6:S1673-8527(22)00090-X (cover story).

Tian P#, Zhong M#, Wei GH*. Mechanistic insights into genetic susceptibility to prostate cancer. Cancer Letters. 2021 Sep 22; 522:155-163.

Ahmed M#, Soares F#, Xia JH#, Yang Y, Li J, Guo H, Su P, Tian Y, Lee JH, Wang M, Akhtar N, Houlahan KE, Bosch A, Zhou S, Mazrooei P, Hua J, Chen S, Petricca J, Zeng Y, Davies A, Fraser M, Quigley DA, Feng F, Boutros PC, Lupien M, Zoubeidi A, Wang L, Walsh MJ, Wang T, Ren S*, Wei GH*, He HH*. CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer, Nature Communications. 2021 Mar 19; 12(1):1781.

Gao P#, Xia JH#, Sipeky C, Dong XM, Zhang Q, Yang Y, Zhang P, Cruz SP, Zhang K, Zhu J, Lee HM, Suleman S, Giannareas N, Liu S; PRACTICAL Consortium, Tammela TLJ, Auvinen A, Wang X, Huang Q, Wang L, Manninen A, Vaarala MH, Wang L, Schleutker J, Wei GH*. Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus. Cell. 2018. 174:576-589.

Previewed in Bulger M. Changing the Guard at a Prostate Cancer SNP. Cell. 174:501-502, 2018
Highlighted in Bradley C. Mechanistic insights into a non-coding risk SNP. Nature ReviewsUrology15:655, 2018
Invited author's views: Xia JH & Wei GH. Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness. Molecular & Cellular Oncology. 5(6):e1516451. 2018

Huang Q#, Whitington T#, Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J*, Wei GH*. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. Nature Genetics. 2014. 46:126-135.

Previewed in HOXB13, RFX6 and prostate cancer risk. Nature Genetics. 46:94-95, 2014

Highlighted in Prostate cancer: HOXB13 and a SNP collaborate to increase risk. Nature Reviews Urology. 11:64, 2014
Research Watch A Prostate Cancer–Associated SNP Increases HOXB13 Binding. Cancer Discovery4:268, 2014
Recommended by Faculty of 1000: ★★ Very Good, good for teaching, new finding. In F1000Prime, 27 Jan 2014; DOI: 10.3410/f.718228195.793490008
News in JNCI: Journal of the National Cancer Institute, 2014
Eturauhassyöpään johtava geenimuutos löytyi Oulussa. HELSINGIN SANOMAT Jan 10 2014

Whitington T#, Gao P#, Song W, Ross-Adams H, Lamb AD, Yang Y, Svezia I, Klevebring D, Mills IG, Karlsson R, Halim S, Dunning MJ, Egevad L, Warren AY, Neal DE, Grönberg H, Lindberg J, Wei GH (joint supervision), Wiklund F. Gene regulatory mechanisms underpinning prostate cancer susceptibility. Nature Genetics. 2016. 48:387-397.

Research Watch Prostate Cancer Risk Loci Are Associated with Gene Regulatory Mechanisms. Cancer Discovery 6:OF13, 2016

Zhang P#, Xia J#, Zhu J, Gao P, Tian YJ, Du M, Guo CY, Suleman S, Zhang Q, Kohli M, Tillmans L, Thibodeau SN, French AJ, Cerhan JR, Wang LD*, Wei GH*, Wang L*. High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing. Nature Communications. 2018. 9, 2022.

Sipeky C#, Gao P#, Zhang Q, Wang L, Ettala O, Talala K, Tammela TL, Auvinen A, Wiklund F, Wei GH*, Schleutker J*. Synergistic interaction of HOXB13 and CIP2A predispose to aggressive prostate cancer. Clinical Cancer Research. 2018. 15;24(24):6265-6276.